Article
The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals.
Neuron - 20 Dec 2007
Mani Meera, Lee Sang Yoon, Lucast Louise, Cremona Ottavio, Di Paolo Gilbert, De Camilli Pietro, Ryan Timothy A
Abstract excerpt
Phosphoinositides have been implicated in synaptic vesicle recycling largely based on studies of enzymes that regulate phosphoinositide synthesis and hydrolysis. One such enzyme is synaptojanin1, a multifunctional protein conserved from yeast to humans, which contains two phosphoinositol phosphatase domains and a proline-rich domain. Genetic ablation of synaptojanin1 leads to pleiotropic defects in presynaptic...
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