Article

Local regulation of extracellular vesicle traffic by the synaptic endocytic machinery

2021-08-05

Abstract excerpt

Neuronal extracellular vesicles (EVs) can be locally released from presynaptic terminals, carrying cargoes that are important in intercellular signaling and disease. EVs are derived from endosomes, but it remains unclear how synaptic cargoes are directed to the EV pathway, rather than undergoing conventional retrograde endosomal transport and degradation. Here, we find that the clathrin-mediated endocytic machiner...

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Literature Corpus work: 0406bec8-1dc7-5464-be6f-e01c8ccf065d
DOI: 10.1101/2021.08.04.454987

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