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Article

Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins.

Cell - 1 Apr 2011

Uytterhoeven Valerie, Kuenen Sabine, Kasprowicz Jaroslaw, Miskiewicz Katarzyna, Verstreken Patrik

Abstract excerpt

Exchange of proteins at sorting endosomes is not only critical to numerous signaling pathways but also to receptor-mediated signaling and to pathogen entry into cells; however, how this process is regulated in synaptic vesicle cycling remains unexplored. In this work, we present evidence that loss of function of a single neuronally expressed GTPase activating protein (GAP), Skywalker (Sky) facilitates endosomal...

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PMID: 21458671
DOI: 10.1016/j.cell.2011.02.039

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