Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer.

BMC cancer - 14 Mar 2015

Birgisson Helgi, Edlund Karolina, Wallin Ulrik, Påhlman Lars, Kultima Hanna Göransson, Mayrhofer Markus, Micke Patrick, Isaksson Anders, Botling Johan, Glimelius Bengt, Sundström Magnus

Abstract excerpt

BACKGROUND: Molecular alterations are well studied in colon cancer, however there is still need for an improved understanding of their prognostic impact. This study aims to characterize colon cancer with regard to KRAS, BRAF, and PIK3CA mutations, microsatellite instability (MSI), and average DNA copy number, in connection with tumour dissemination and recurrence in patients with colon cancer. METHODS: Disease...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Follow-Up Studies

Share to Mutation

Share to Predictive Value of Tests

Share to Proto-Oncogene Proteins

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 25884297
DOI: 10.1186/s12885-015-1144-x
PMCID: PMC4364587

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer.PMID 25884297Read ↗

Molecular profiling of the colon cancer in South-Eastern Romania: Results from the MERCUR study.Semantic proximity Read ↗

High tumor mutational burden assessed through next-generation sequencing predicts favorable survival in microsatellite stable metastatic colon cancer patients.Semantic proximity Read ↗

Prognostic and clinicopathologic significance of BRAF mutation in colon cancer by MSI status and stage: A large cohort analysis.Semantic proximity Read ↗

The prognostic role of microsatellite instability, codon-specific KRAS, and BRAF mutations in colon cancer.Semantic proximity Read ↗

Genetic alterations in locally advanced stage II/III colon cancer: a search for prognostic markers.Semantic proximity Read ↗

Molecular Characterization of Sporadic Colorectal Cancer: Association Between KRAS, NRAS, and BRAF Mutations and Microsatellite Instability via Next-Generation SequencingSemantic proximity Read ↗

Microsatellite Instability in Greek Colorectal Carcinoma Patients: Clinicopathological and Molecular Correlations.Semantic proximity Read ↗

Genomic and immunological features of microsatellite instability in colon cancer.Semantic proximity Read ↗

Elucidating the Role of KRAS, NRAS, and BRAF Mutations and Microsatellite Instability in Colorectal Cancer via Next-Generation SequencingSemantic proximity Read ↗

Comprehensive analysis of copy number aberrations in microsatellite stable colon cancer in view of stromal component.Semantic proximity Read ↗

Genetic and molecular diversity of colon cancer hepatic metastases.Semantic proximity Read ↗

Molecular Subtypes in Stage II-III Colon Cancer Defined by Genomic Instability: Early Recurrence-Risk Associated with a High Copy-Number Variation and Loss of RUNX3 and CDKN2ASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.