Article
Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer.
BMC cancer - 14 Mar 2015
Birgisson Helgi, Edlund Karolina, Wallin Ulrik, Påhlman Lars, Kultima Hanna Göransson, Mayrhofer Markus, Micke Patrick, Isaksson Anders, Botling Johan, Glimelius Bengt, Sundström Magnus
Abstract excerpt
BACKGROUND: Molecular alterations are well studied in colon cancer, however there is still need for an improved understanding of their prognostic impact. This study aims to characterize colon cancer with regard to KRAS, BRAF, and PIK3CA mutations, microsatellite instability (MSI), and average DNA...
Topics
- Aged
- Colonic Neoplasms
- Female
- Follow-Up Studies
- Humans
- Male
- Microsatellite Instability
- Mutation
- Predictive Value of Tests
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins B-raf
- Proto-Oncogene Proteins p21(ras)
- ras Proteins