Article
Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer.
Cancer - 15 Oct 2011
Tran Ben, Kopetz Scott, Tie Jeanne, Gibbs Peter, Jiang Zhi-Qin, Lieu Christopher H, Agarwal Atin, Maru Dipen M, Sieber Oliver, Desai Jayesh
Abstract excerpt
BACKGROUND: It is hypothesized that BRAF mutant cancers represent a discrete subset of metastatic colorectal cancer (CRC) defined by poorer survival. This study investigates whether BRAF mutant CRC is further defined by a distinct pattern of metastatic spread and explores the impact of BRAF mutation and microsatellite instability (MSI) on prognosis in metastatic CRC. METHODS: By using prospective clinical data...
Topics
- Aged
- Aged, 80 and over
- Colorectal Neoplasms
- Female
- Humans
- Kaplan-Meier Estimate
- Male
- Microsatellite Instability
- Middle Aged
- Multivariate Analysis
- Mutation
- Predictive Value of Tests
- Prognosis