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Article

Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer.

Cancer - 15 Oct 2011

Tran Ben, Kopetz Scott, Tie Jeanne, Gibbs Peter, Jiang Zhi-Qin, Lieu Christopher H, Agarwal Atin, Maru Dipen M, Sieber Oliver, Desai Jayesh

Abstract excerpt

BACKGROUND: It is hypothesized that BRAF mutant cancers represent a discrete subset of metastatic colorectal cancer (CRC) defined by poorer survival. This study investigates whether BRAF mutant CRC is further defined by a distinct pattern of metastatic spread and explores the impact of BRAF mutation and microsatellite instability (MSI) on prognosis in metastatic CRC. METHODS: By using prospective clinical data...

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Source

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Identifiers

PMID: 21456008
DOI: 10.1002/cncr.26086
PMCID: PMC4257471

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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