Article
Divergent oncogenic changes influence survival differences between colon and rectal adenocarcinomas.
Diseases of the colon and rectum - 1 Jun 2009
Kalady Matthew F, Sanchez Julian A, Manilich Elena, Hammel Jeff, Casey Graham, Church James M
Abstract excerpt
PURPOSE: Colorectal cancers develop through various mechanisms such as chromosomal instability, DNA mismatch repair deficiency (microsatellite instability), and epigenetic DNA promoter methylation (CpG island methylator phenotype). This study evaluated the disparity in neoplastic changes between...
Topics
- Adenocarcinoma
- Adult
- Chi-Square Distribution
- Colonic Neoplasms
- CpG Islands
- DNA Methylation
- DNA Mutational Analysis
- Female
- Humans
- Male
- Microsatellite Instability
- Middle Aged
- Neoplasm Staging
- Phenotype
- Proportional Hazards Models
- Proto-Oncogene Proteins B-raf
- Rectal Neoplasms
- Statistics, Nonparametric