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Article

Divergent oncogenic changes influence survival differences between colon and rectal adenocarcinomas.

Diseases of the colon and rectum - 1 Jun 2009

Kalady Matthew F, Sanchez Julian A, Manilich Elena, Hammel Jeff, Casey Graham, Church James M

Abstract excerpt

PURPOSE: Colorectal cancers develop through various mechanisms such as chromosomal instability, DNA mismatch repair deficiency (microsatellite instability), and epigenetic DNA promoter methylation (CpG island methylator phenotype). This study evaluated the disparity in neoplastic changes between colon and rectal cancers. METHODS: A clinic-based colorectal frozen tumor bank at a single institution was queried for...

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Source

Identifiers

PMID: 19581844
DOI: 10.1007/DCR.0b013e31819edbd4

Genes

BRAF
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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