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Article

Mutations in the Kirsten-ras oncogene are common but lack correlation with prognosis and tumor stage in human pancreatic carcinoma.

The American journal of gastroenterology - 1 Dec 1991

Motojima K, Urano T, Nagata Y, Shiku H, Tsunoda T, Kanematsu T

Abstract excerpt

Utilizing the polymerase chain reaction (PCR), we studied the presence and pattern of mutations in the Kirsten (Ki)-ras oncogene, using paraffin-embedded sections of pancreatic carcinoma tissue from 53 patients. Mutations in the Ki-ras oncogene were evident in 46 of the 53 patients (87%) in codon 12. The predominant mutation was from glycine (GGT) to aspartic acid (GAT). Among the 46, one had an additional...

Topics

Adenocarcinoma
Aged
Cystadenocarcinoma
Female
Genes, ras
Humans
Male
Middle Aged
Mutation
Neoplasm Staging
Nucleic Acid Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pancreatic Neoplasms

Polymerase Chain Reaction

Prognosis

Survival Rate

Source

Identifiers

PMID: 1962623

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1962623-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mutations in the Kirsten-ras oncogene are common but lack correlation with prognosis and tumor stage in human pancreatic carcinoma.PMID 1962623Read ↗

Distinguishing pancreatic carcinoma from other periampullary carcinomas by analysis of mutations in the Kirsten-ras oncogene.Semantic proximity Read ↗

Only wild-type c-Ki-ras codons 12, 13, and 61 in human pancreatic acinar cell carcinomas.Semantic proximity Read ↗

Ki-ras mutations in exocrine pancreatic cancer: association with clinico-pathological characteristics and with tobacco and alcohol consumption. PANK-ras I Project Investigators.Semantic proximity Read ↗

Detection of codon 12 mutation in the K-ras oncogene in pancreatic tumors.Semantic proximity Read ↗

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Detection of Point Mutations in the Kirsten-ras Oncogene Provides Evidence for the Multicentricity of Pancreatic CarcinomaSemantic proximity Read ↗

Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction.Semantic proximity Read ↗

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Mutations in the ras protooncogenes are rare events in renal cell cancer.Semantic proximity Read ↗

Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors.Semantic proximity Read ↗

Glycine to aspartic acid mutations at codon 13 of the c-Ki-ras gene in human gastrointestinal cancers.Semantic proximity Read ↗

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