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Article

Distinguishing pancreatic carcinoma from other periampullary carcinomas by analysis of mutations in the Kirsten-ras oncogene.

Annals of surgery - 1 Dec 1991

Motojima K, Tsunoda T, Kanematsu T, Nagata Y, Urano T, Shiku H

Abstract excerpt

The prevalence of Kirsten (Ki)-ras gene mutations was studied in 105 paraffin-embedded tissues obtained from 40 patients with pancreatic cancer, 48 with bile duct carcinoma (19 distal, 6 middle, and 23 proximal), 16 with ampullary carcinoma and 1 with duodenal cancer, by in vitro amplification of target sequences by the polymerase chain reaction (PCR). With regard to pancreatic cancers, the authors' data confirm...

Topics

Aged
Ampulla of Vater
Bile Duct Neoplasms
Common Bile Duct Neoplasms
Duodenal Neoplasms
Female
Gene Amplification
Genes, ras
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Pancreatic Neoplasms

Paraffin Embedding

Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 1741644
DOI: 10.1097/00000658-199112000-00003
PMCID: PMC1358488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1741644-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Distinguishing pancreatic carcinoma from other periampullary carcinomas by analysis of mutations in the Kirsten-ras oncogene.PMID 1741644Read ↗

Mutations in the Kirsten-ras oncogene are common but lack correlation with prognosis and tumor stage in human pancreatic carcinoma.Semantic proximity Read ↗

Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction.Semantic proximity Read ↗

Detection of mutated c-Ki-ras in the bile of patients with pancreatic cancer.Semantic proximity Read ↗

Detection of c-Ki-ras mutation by PCR/RFLP analysis and diagnosis of pancreatic adenocarcinomas.Semantic proximity Read ↗

Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing.Semantic proximity Read ↗

Detection of Point Mutations in the Kirsten-ras Oncogene Provides Evidence for the Multicentricity of Pancreatic CarcinomaSemantic proximity Read ↗

Ki-ras mutations in exocrine pancreatic cancer: association with clinico-pathological characteristics and with tobacco and alcohol consumption. PANK-ras I Project Investigators.Semantic proximity Read ↗

Detection of codon 12 mutation in the K-ras oncogene in pancreatic tumors.Semantic proximity Read ↗

Detection of Ki-ras oncogene mutations in pancreatic diseases: helpful or irrelevant?Semantic proximity Read ↗

K-ras mutations in the duodenal fluid of patients with pancreatic carcinoma.Semantic proximity Read ↗

Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma.Semantic proximity Read ↗

K-Ras mutations and benign pancreatic disease.Semantic proximity Read ↗

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