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Article

Mutations in the ras protooncogenes are rare events in renal cell cancer.

European journal of cancer (Oxford, England : 1990) - 1 Jan 1992

Rochlitz C F, Peter S, Willroth G, de Kant E, Lobeck H, Huhn D, Herrmann R

Abstract excerpt

Mutations in codon 12, 13 or 61 of one of the three ras genes, Ha-ras, Ki-ras, and N-ras, convert these genes into active oncogenes. To determine the role mutated ras genes play in the carcinogenesis of renal cell carcinoma, we analysed tumour DNA and unaffected renal tissue derived from 55 patients. The polymerase chain reaction technique was used to amplify DNA fragments containing Ki-, Ha-, and N-ras codons...

Topics

Adult
Aged
Aged, 80 and over
Carcinoma, Renal Cell
Cell Transformation, Neoplastic
Female
Genes, ras
Humans
Kidney Neoplasms
Male
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oligonucleotide Probes

Polymerase Chain Reaction

Source

Identifiers

PMID: 1591047
DOI: 10.1016/s0959-8049(05)80048-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1591047-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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