Article
Detection of codon 12 mutation in the K-ras oncogene in pancreatic tumors.
Revista do Hospital das Clinicas - 1 Jan 2000
Kubrusly M S, Matheucci Júnior E, Leite K R, Coelho A M, Monte O, Machado M C, Pinotti H W
Abstract excerpt
Mutations at codons 12, 13, or 61 of the H-ras, K-ras, and N-ras have been detected in human neoplasias by a variety of techniques. Some of these techniques are very sensitive and can detect K-ras mutation in 90% of the cases of pancreatic adenocarcinomas. We analyzed 11 samples of pancreatic adenocarcinoma, three samples of pancreatic mucinous cystadenoma, and two samples without tumors in formalin-fixed...
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