Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors.

doi:10.1289/ehp.9193125

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Article

Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors.

Environmental health perspectives - 1 Jun 1991

Capella G, Cronauer-Mitra S, Pienado M A, Perucho M

Abstract excerpt

The frequency of point mutations at codons 12 and 13 of the c-K-ras gene has been determined in a panel of more than 400 human tumors. Mutant c-K-ras genes were detected in about 75% of adenocarcinomas of the pancreas (n = 84); 40% of adenomas (n = 72) and carcinomas (n = 244) of the colon end rectum; 30% of carcinomas of the bile duct (n = 19); 25% of carcinomas of the lung (n = 92), and in lower frequency in...

Topics

Base Sequence
Carcinoma
Cell Transformation, Neoplastic
Codon
DNA, Neoplasm
Digestive System Neoplasms
GTP Phosphohydrolases
GTP-Binding Proteins
GTPase-Activating Proteins
Genes, ras
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lung Neoplasms

Molecular Sequence Data

Multigene Family

Mutation

Neoplasms

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Source

Open in PubMed Open full text

Identifiers

PMID: 1685441
DOI: 10.1289/ehp.9193125
PMCID: PMC1568052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1685441-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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