Article
Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction.
Oncogene - 1 May 1991
Stork P, Loda M, Bosari S, Wiley B, Poppenhusen K, Wolfe H
Abstract excerpt
Mutations within codon 12 leading to activation of Kirsten-ras (K-ras) genes occur in a wide variety of human tumors, but have been reported most frequently in pancreatic carcinomas. We studied twenty-four paraffin-embedded pancreatic and hepatic tumors and two colon carcinoma cell lines with a r...
Topics
- Amino Acid Sequence
- Base Sequence
- Carcinoma, Hepatocellular
- Cell Line
- Codon
- Colonic Neoplasms
- DNA, Neoplasm
- Exons
- Genes, ras
- Humans
- Liver Neoplasms
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Pancreatic Neoplasms
- Polymerase Chain Reaction