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Article

KRAS mutations in codon 12 or 13 are associated with worse prognosis in pancreatic ductal adenocarcinoma.

Pancreas - 1 May 2014

Sinn Bruno V, Striefler Jana K, Rudl Marc A, Lehmann Annika, Bahra Marcus, Denkert Carsten, Sinn Marianne, Stieler Jens, Klauschen Frederick, Budczies Jan, Weichert Wilko, Stenzinger Albrecht, Kamphues Carsten, Dietel Manfred, Riess Hanno

Abstract excerpt

OBJECTIVE: Mutations in the KRAS and P53 genes belong to the most frequently observed genetic alterations in pancreatic ductal adenocarcinoma. The aim of this study was to examine the frequency and prognostic impact of KRAS mutations. In addition, we attempted to define molecular subgroups with distinct biologic behavior by combination of KRAS sequencing data with p53 protein expression data. METHODS: KRAS...

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PMID: 24681874
DOI: 10.1097/MPA.0000000000000077

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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