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Article

Mouse kappa light-chain recombination signal sequences mediate recombination more frequently than do those of lambda light chain.

1 Dec 1991

Abstract excerpt

Immunoglobulin and T-cell receptor genes are somatically rearranged by site-specific recombination. Recombination signal sequences (RSS) have been identified as the major targeting element of this process. Recent reports demonstrate that differences in RSS affect the frequency of recombination, suggesting a role for RSS in the development of the B-cell repertoire. Examination of mouse light-chain RSS indicates...

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PMID: 1961738
DOI: 10.1073/pnas.88.23.10721

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Source receipt: pubmed, retrieved 7 Sept 2026.

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