Article
Mechanistic and selective constraints act on the establishment of V lambda J lambda junctions in the B cell repertoire.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1994
Boudinot P, Drapier A M, Cazenave P A, Sanchez P
Abstract excerpt
Only four different subtypes of lambda Ig chains have been described in the mouse: lambda 1, lambda 2(V2), lambda 2(Vx), and lambda 3. These chains are encoded by gene segments all sequenced and well localized in chromosome 16. Although the lambda Ig system is both simple and well characterized,...
Topics
- Amino Acid Sequence
- Animals
- Antibody Diversity
- B-Lymphocytes
- Base Sequence
- Cloning, Molecular
- DNA Primers
- DNA, Complementary
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Immunoglobulin Joining Region
- Immunoglobulin Variable Region
- Immunoglobulin lambda-Chains
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction