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Article

Restrictions limiting the generation of DNA double strand breaks during chromosomal V(D)J recombination.

The Journal of experimental medicine - 4 Feb 2002

Tillman Robert E, Wooley Andrea L, Hughes Maureen M, Wehrly Tara D, Swat Wojciech, Sleckman Barry P

Abstract excerpt

Antigen receptor loci are composed of numerous variable (V), diversity (D), and joining (J) gene segments, each flanked by recombination signal sequences (RSSs). The V(D)J recombination reaction proceeds through RSS recognition and DNA cleavage steps making it possible for multiple DNA double strand breaks (DSBs) to be introduced at a single locus. Here we use ligation-mediated PCR to analyze DNA cleavage...

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Identifiers

PMID: 11828005
DOI: 10.1084/jem.20011803
PMCID: PMC2193590

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Source receipt: pubmed, retrieved 7 Sept 2026.

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