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Article

RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetes

15 Dec 2008

Abstract excerpt

Continued antibody gene rearrangement, termed receptor editing, is an important mechanism of central B cell tolerance that may be defective in some autoimmune individuals. We describe a quantitative assay for recombining sequence (RS) rearrangement that we use to estimate levels of antibody light chain receptor editing in various B cell populations. RS rearrangement is a recombination of a noncoding gene segment...

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PMID: 19075293
DOI: 10.1084/jem.20082053

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