Article
Unequal VH gene rearrangement frequency within the large VH7183 gene family is not due to recombination signal sequence variation, and mapping of the genes shows a bias of rearrangement based on chromosomal location.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2001
Williams G S, Martinez A, Montalbano A, Tang A, Mauhar A, Ogwaro K M, Merz D, Chevillard C, Riblet R, Feeney A J
Abstract excerpt
Much of the nonrandom usage of V, D, and J genes in the Ab repertoire is due to different frequencies with which gene segments undergo V(D)J rearrangement. The recombination signal sequences flanking each segment are seldom identical with consensus sequences, and this natural variation in recombination signal sequence (RSS) accounts for some differences in rearrangement frequencies in vivo. Here, we have...
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