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Article

Regulation of early neurite morphogenesis by the Na+/H+ exchanger NHE1.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jul 2009

Sin Wun-Chey, Moniz David M, Ozog Mark A, Tyler Jessica E, Numata Masayuki, Church John

Abstract excerpt

The ubiquitously expressed Na(+)/H(+) exchanger NHE1 plays an important role in regulating polarized membrane protrusion and directional motility in non-neuronal cells. Using NGF-differentiated PC12 cells and murine neocortical neurons in vitro, we now show that NHE1 plays a role in regulating early neurite morphogenesis. NHE1 was expressed in growth cones in which it gave rise to an elevated intracellular pH in...

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Identifiers

PMID: 19605632
DOI: 10.1523/JNEUROSCI.2030-09.2009
PMCID: PMC2878814

Genes

BDNF
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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