Constitutive overexpression of the basic helix-loop-helix Nex1/MATH-2 transcription factor promotes neuronal differentiation of PC12 cells and neurite regeneration.

Abstract excerpt

Elucidation of the intricate transcriptional pathways leading to neural differentiation and the establishment of neuronal identity is critical to the understanding and design of therapeutic approaches. Among the important players, the basic helix-loop-helix (bHLH) transcription factors have been found to be pivotal regulators of neurogenesis. In this study, we investigate the role of the bHLH differentiation...

Topics

• Animals
• Basic Helix-Loop-Helix Transcription Factors
• Cell Cycle
• Cell Differentiation
• Central Nervous System
• Cyclin-Dependent Kinase Inhibitor p21
• Cyclins
• GAP-43 Protein
• Gene Expression Regulation
• Helix-Loop-Helix Motifs
• Mutation
• Nerve Growth Factor