Article
Involvement of the Na+/Ca2+ exchanger isoform 1 (NCX1) in neuronal growth factor (NGF)-induced neuronal differentiation through Ca2+-dependent Akt phosphorylation.
The Journal of biological chemistry - 16 Jan 2015
Secondo Agnese, Esposito Alba, Sirabella Rossana, Boscia Francesca, Pannaccione Anna, Molinaro Pasquale, Cantile Maria, Ciccone Roselia, Sisalli Maria Josè, Scorziello Antonella, Di Renzo Gianfranco, Annunziato Lucio
Abstract excerpt
NGF induces neuronal differentiation by modulating [Ca(2+)]i. However, the role of the three isoforms of the main Ca(2+)-extruding system, the Na(+)/Ca(2+) exchanger (NCX), in NGF-induced differentiation remains unexplored. We investigated whether NCX1, NCX2, and NCX3 isoforms could play a relevant role in neuronal differentiation through the modulation of [Ca(2+)]i and the Akt pathway. NGF caused progressive...
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