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EGF upregulates Na<sup>+</sup>/H<sup>+</sup> exchanger NHE1 by post‐translational regulation that is important for cervical cancer cell invasiveness

25 Sept 2007

Abstract excerpt

Na+/H+ exchanger 1 (NHE1) is involved in cell migration but little is known about the signal pathways that regulate NHE1 activity and that are associated with tumor cell invasiveness. This study is to investigate the mechanisms by which epidermal growth factor (EGF) regulates NHE1 expression to promote cervical cancer cell invasiveness and the clinical significance in early-stage cervical cancer. NHE1 protein was...

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PMID: 17894388
DOI: 10.1002/jcp.21277

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