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Fibroblast growth factor 14 is an intracellular modulator of voltage‐gated sodium channels

15 Sept 2005

Abstract excerpt

Genetic ablation of the fibroblast growth factor (Fgf) 14 gene in mice or a missense mutation in Fgf14 in humans causes ataxia and cognitive deficits. These phenotypes suggest that the neuronally expressed Fgf14 gene is essential for regulating normal neuronal activity. Here, we demonstrate that FGF14 interacts directly with multiple voltage-gated Na(+) (Nav) channel alpha subunits heterologously expressed in...

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PMID: 16166153
DOI: 10.1113/jphysiol.2005.097220

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