Persistent Lin28 Expression Impairs Neurite Outgrowth and Cognitive Function in the Developing Mouse Neocortex.

doi:10.1007/s12035-018-1297-0

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Article

Persistent Lin28 Expression Impairs Neurite Outgrowth and Cognitive Function in the Developing Mouse Neocortex.

Molecular neurobiology - 1 May 2019

Jang Hyun-Jong, Kim Joo Youn, Kim Seong Yun, Cho Kyung-Ok

Abstract excerpt

Many neurodevelopmental disorders feature learning and memory difficulties. Regulation of neurite outgrowth during development is critical for neural plasticity and memory function. Here, we show a novel regulator of neurite outgrowth during cortical neurogenesis, Lin28, which is an RNA-binding protein. Persistent Lin28 upregulation by in utero electroporation at E14.5 resulted in neurite underdevelopment during...

Topics

Action Potentials
Animals
Cerebral Cortex
Cognition
Female
Gene Silencing
Green Fluorescent Proteins
Lysine
Mice, Inbred C57BL
Neocortex
Neurites
Neurogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuronal Outgrowth

Phenotype

RNA, Small Interfering

RNA-Binding Proteins

Synapses

Up-Regulation

Source

Open in PubMed

Identifiers

PMID: 30203263
DOI: 10.1007/s12035-018-1297-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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