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Article

Genetic inactivation of poliovirus infectivity by increasing the frequencies of CpG and UpA dinucleotides within and across synonymous capsid region codons.

Journal of virology - 1 Oct 2009

Burns Cara C, Campagnoli Ray, Shaw Jing, Vincent Annelet, Jorba Jaume, Kew Olen

Abstract excerpt

Replicative fitness of poliovirus can be modulated systematically by replacement of preferred capsid region codons with synonymous unpreferred codons. To determine the key genetic contributors to fitness reduction, we introduced different sets of synonymous codons into the capsid coding region of an infectious clone derived from the type 2 prototype strain MEF-1. Replicative fitness in HeLa cells, measured by...

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Identifiers

PMID: 19605476
DOI: 10.1128/JVI.00508-09
PMCID: PMC2747992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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