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Article

Synonymous Codon Pair Recoding of the HIV-1 env Gene Affects Virus Replication Capacity.

Cells - 29 Jun 2021

Jordan-Paiz Ana, Franco Sandra, Martinez Miguel Angel

Abstract excerpt

Synonymous codon pair deoptimization is an efficient strategy for virus attenuation; however, the underlying mechanism remains controversial. Here, we optimized and deoptimized the codon pair bias (CPB) of the human immunodeficiency virus type 1 (HIV-1) envelope (env) gene to investigate the influence of env synonymous CPB recoding on virus replication capacity, as well as the potential mechanism. We found that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34209946
DOI: 10.3390/cells10071636
PMCID: PMC8304268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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