Article
Random codon re-encoding induces stable reduction of replicative fitness of Chikungunya virus in primate and mosquito cells.
PLoS pathogens - 1 Feb 2013
Nougairede Antoine, De Fabritus Lauriane, Aubry Fabien, Gould Ernest A, Holmes Edward C, de Lamballerie Xavier
Abstract excerpt
Large-scale codon re-encoding represents a powerful method of attenuating viruses to generate safe and cost-effective vaccines. In contrast to specific approaches of codon re-encoding which modify genome-scale properties, we evaluated the effects of random codon re-encoding on the re-emerging human pathogen Chikungunya virus (CHIKV), and assessed the stability of the resultant viruses during serial in cellulo...
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