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Changes in codon-pair bias of human immunodeficiency virus type 1 have profound effects on virus replication in cell culture

25 Jul 2013

Abstract excerpt

BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) has a biased nucleotide composition different from human genes. This raises the question of how evolution has chosen the nucleotide sequence of HIV-1 that is observed today, or to what extent the actual encoding contributes to virus replication capacity, evolvability and pathogenesis. Here, we applied the previously described synthetic attenuated virus...

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PMID: 23885919
DOI: 10.1186/1742-4690-10-78

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