Article
The influence of CpG and UpA dinucleotide frequencies on RNA virus replication and characterization of the innate cellular pathways underlying virus attenuation and enhanced replication.
Nucleic acids research - 1 Apr 2014
Atkinson Nicky J, Witteveldt Jeroen, Evans David J, Simmonds Peter
Abstract excerpt
Most RNA viruses infecting mammals and other vertebrates show profound suppression of CpG and UpA dinucleotide frequencies. To investigate this functionally, mutants of the picornavirus, echovirus 7 (E7), were constructed with altered CpG and UpA compositions in two 1.1-1.3 Kbase regions. Those with increased frequencies of CpG and UpA showed impaired replication kinetics and higher RNA/infectivity ratios...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.