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Article

Attenuation of Human Respiratory Viruses by Synonymous Genome Recoding

4 Jun 2019

Abstract excerpt

Using computer algorithms and commercial DNA synthesis, one or more ORFs of a microbial pathogen such as a virus can be recoded and deoptimized by several strategies that may involve the introduction of up to thousands of nucleotide (nt) level without affecting amino acid (aa) coding. The synonymous recoding strategies that have been applied to RNA viruses include: deoptimization of codon or codon-pair usage,...

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PMID: 31231383
DOI: 10.3389/fimmu.2019.01250

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