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Article

Evidence for Strong Mutation Bias toward, and Selection against, U Content in SARS-CoV-2: Implications for Vaccine Design.

Molecular biology and evolution - 4 Jan 2021

Rice Alan M, Castillo Morales Atahualpa, Ho Alexander T, Mordstein Christine, Mühlhausen Stefanie, Watson Samir, Cano Laura, Young Bethan, Kudla Grzegorz, Hurst Laurence D

Abstract excerpt

Large-scale re-engineering of synonymous sites is a promising strategy to generate vaccines either through synthesis of attenuated viruses or via codon-optimized genes in DNA vaccines. Attenuation typically relies on deoptimization of codon pairs and maximization of CpG dinucleotide frequencies. So as to formulate evolutionarily informed attenuation strategies that aim to force nucleotide usage against the...

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Identifiers

PMID: 32687176
DOI: 10.1093/molbev/msaa188
PMCID: PMC7454790

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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