Article
TCF7L2 is a master regulator of insulin production and processing.
Human molecular genetics - 15 Dec 2014
Zhou Yuedan, Park Soo-Young, Su Jing, Bailey Kathleen, Ottosson-Laakso Emilia, Shcherbina Liliya, Oskolkov Nikolay, Zhang Enming, Thevenin Thomas, Fadista João, Bennet Hedvig, Vikman Petter, Wierup Nils, Fex Malin, Rung Johan, Wollheim Claes, Nobrega Marcelo, Renström Erik, Groop Leif, Hansson Ola
Abstract excerpt
Genome-wide association studies have revealed >60 loci associated with type 2 diabetes (T2D), but the underlying causal variants and functional mechanisms remain largely elusive. Although variants in TCF7L2 confer the strongest risk of T2D among common variants by presumed effects on islet function, the molecular mechanisms are not yet well understood. Using RNA-sequencing, we have identified a TCF7L2-regulated...
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