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Article

<i>TCF7L2</i> is a master regulator of insulin production and processing

2014-03-05

Abstract excerpt

Although variants in the T-cell factor 7-like 2 gene ( TCF7L2 ) confer the strongest risk of type 2 diabetes (T2D) by presumed effects on islet function, the underlying mechanisms are not well understood. We have identified TCF7L2-target genes and described the regulatory network downstream of TCF7L2 responsible for its effect on insulin secretion in rodents and human pancreatic islets. ISL1 is a direct target o...

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Identifiers and source

Literature Corpus work
92e4ff4f-2aa3-5136-818b-4df727aad572
DOI
10.1101/003202
Open publication

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<i>TCF7L2</i> is a master regulator of insulin production and processingDOI 10.1101/003202
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