Article
Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias.
Molecular immunology - 1 Apr 2007
Xiao Zheng, Ray Madhumita, Jiang Chuancang, Clark Alan B, Rogozin Igor B, Diaz Marilyn
Abstract excerpt
The basis for mutations at A:T base pairs in immunoglobulin hypermutation and defining how AID interacts with the DNA of the immunoglobulin locus are major aspects of the immunoglobulin mutator mechanism where questions remain unanswered. Here, we examined the pattern of mutations generated in mice deficient in various DNA repair proteins implicated in A:T mutation and found a previously unappreciated bias at G:C...
Topics
- Adenosine Triphosphate
- Animals
- Burkitt Lymphoma
- Cell Line, Tumor
- Cytidine Deaminase
- Cytidine Triphosphate
- DNA Mismatch Repair
- DNA Repair Enzymes
- Guanosine Triphosphate
- Humans
- Mice
- Mutation
- Nucleotides
- Somatic Hypermutation, Immunoglobulin