Article
Proximity to AGCT sequences dictates MMR-independent versus MMR-dependent mechanisms for AID-induced mutation via UNG2.
Nucleic acids research - 7 Apr 2017
Thientosapol Eddy Sanchai, Sharbeen George, Lau K K Edwin, Bosnjak Daniel, Durack Timothy, Stevanovski Igor, Weninger Wolfgang, Jolly Christopher J
Abstract excerpt
AID deaminates C to U in either strand of Ig genes, exclusively producing C:G/G:C to T:A/A:T transition mutations if U is left unrepaired. Error-prone processing by UNG2 or mismatch repair diversifies mutation, predominantly at C:G or A:T base pairs, respectively. Here, we show that transversions at C:G base pairs occur by two distinct processing pathways that are dictated by sequence context. Within and near...
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