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Article

Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs.

The Journal of experimental medicine - 3 Apr 2017

Girelli Zubani Giulia, Zivojnovic Marija, De Smet Annie, Albagli-Curiel Olivier, Huetz François, Weill Jean-Claude, Reynaud Claude-Agnès, Storck Sébastien

Abstract excerpt

During somatic hypermutation (SHM) of immunoglobulin genes, uracils introduced by activation-induced cytidine deaminase are processed by uracil-DNA glycosylase (UNG) and mismatch repair (MMR) pathways to generate mutations at G-C and A-T base pairs, respectively. Paradoxically, the MMR-nicking complex Pms2/Mlh1 is apparently dispensable for A-T mutagenesis. Thus, how detection of U:G mismatches is translated into...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28283534
DOI: 10.1084/jem.20161576
PMCID: PMC5379981

Genes

UNG
SMUG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs.PMID 28283534Read ↗

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair.Semantic proximity Read ↗

Somatic hypermutation at A/T-rich oligonucleotide substrates shows different strand polarities in Ung-deficient or -proficient backgrounds.Semantic proximity Read ↗

Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation.Semantic proximity Read ↗

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Refining the Neuberger model: Uracil processing by activated B cells.Semantic proximity Read ↗

B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.Semantic proximity Read ↗

The concerted action of Msh2 and UNG stimulates somatic hypermutation at A . T base pairs.Semantic proximity Read ↗

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MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites.Semantic proximity Read ↗

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