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Article

Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2009

Hamilton-Williams Emma E, Martinez Xavier, Clark Jan, Howlett Sarah, Hunter Kara M, Rainbow Daniel B, Wen Li, Shlomchik Mark J, Katz Jonathan D, Beilhack Georg F, Wicker Linda S, Sherman Linda A

Abstract excerpt

In humans and NOD mice, defects in immune tolerance result in the spontaneous development of type-1-diabetes. Recent studies have ascribed a breakdown in tolerance to dysfunction in regulatory T cells that is secondary to reduced IL-2 production by T cells having the NOD diabetes susceptibility region insulin-dependent diabetes 3 (Idd3). In this study, we demonstrate a peripheral tolerance defect in the dendritic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19592648
DOI: 10.4049/jimmunol.0900428
PMCID: PMC2733871

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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