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Article

Reduced numbers of dendritic cells with a tolerogenic phenotype in the prediabetic pancreas of NOD mice.

Journal of leukocyte biology - 1 Dec 2012

Welzen-Coppens Jojanneke M C, van Helden-Meeuwsen Cornelia G, Leenen Pieter J M, Drexhage Hemmo A, Versnel Marjan A

Abstract excerpt

The NOD mouse is a widely used animal model of autoimmune diabetes. Prior to the onset of lymphocytic insulitis, DCs accumulate at the islet edges. Our recent work indicated that these DCs may derive from aberrantly proliferating local precursor cells. As CD8α(+) DCs play a role in tolerance induction in steady-state conditions, we hypothesized that the autoimmune phenotype might associate with deficiencies in...

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Share to CD8 Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Integrin alpha Chains

Share to Lectins, C-Type

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Share to Mice, Inbred NOD

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Source

Identifiers

PMID: 23012431
DOI: 10.1189/jlb.0312168

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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