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Article

Dendritic cells license regulatory B cells to produce IL-10 and mediate suppression of antigen-specific CD8 T cells.

Cellular & molecular immunology - 1 Aug 2020

Boldison Joanne, Da Rosa Larissa Camargo, Davies Joanne, Wen Li, Wong F Susan

Abstract excerpt

Regulatory B cells (Bregs) suppress and reduce autoimmune pathology. However, given the variety of Breg subsets, the role of Bregs in the pathogenesis of type 1 diabetes is still unclear. Here, we dissect this fundamental mechanism. We show that natural protection from type 1 diabetes in nonobese diabetic (NOD) mice is associated with increased numbers of IL-10-producing B cells, while development of type 1...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31728048
DOI: 10.1038/s41423-019-0324-z
PMCID: PMC7395736

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