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Article

Type 1 diabetes genetic susceptibility and dendritic cell function: potential targets for treatment.

Journal of leukocyte biology - 1 Jul 2016

Hotta-Iwamura Chie, Tarbell Kristin V

Abstract excerpt

Type 1 diabetes is an autoimmune disease that results from the defective induction or maintenance of T cell tolerance against islet β cell self-antigens. Under steady-state conditions, dendritic cells with tolerogenic properties are critical for peripheral immune tolerance. Tolerogenic dendritic cells can induce T cell anergy and deletion and, in some contexts, induce or expand regulatory T cells. Dendritic cells...

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Identifiers

PMID: 26792821
DOI: 10.1189/jlb.3MR1115-500R
PMCID: PMC4946618

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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