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Article

Two genetic loci regulate T cell-dependent islet inflammation and drive autoimmune diabetes pathogenesis.

American journal of human genetics - 1 Jul 2000

Fox C J, Paterson A D, Mortin-Toth S M, Danska J S

Abstract excerpt

Insulin-dependent diabetes mellitus (IDDM) is a polygenic disease caused by progressive autoimmune infiltration (insulitis) of the pancreatic islets of Langerhan, culminating in the destruction of insulin-producing beta cells. Genome scans of families with diabetes suggest that multiple loci make incremental contributions to disease susceptibility. However, only the IDDM1 locus is well characterized, at a...

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Identifiers

PMID: 10848492
DOI: 10.1086/302995
PMCID: PMC1287103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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