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Article

Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G proteins at leading edges of moving NIH3T3 cells.

The Journal of biological chemistry - 4 Sept 2009

Miyata Muneaki, Rikitake Yoshiyuki, Takahashi Motonori, Nagamatsu Yuichi, Yamauchi Yusuke, Ogita Hisakazu, Hirata Ken-ichi, Takai Yoshimi

Abstract excerpt

Cyclical activation and inactivation of Rho family small G proteins, such as Rho, Rac, and Cdc42, are needed for moving cells to form leading edge structures in response to chemoattractants. However, the mechanisms underlying the dynamic regulation of their activities are not fully understood. We recently showed that another small G protein, Rap1, plays a crucial role in the platelet-derived growth factor...

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Identifiers

PMID: 19589776
DOI: 10.1074/jbc.M109.016436
PMCID: PMC2782049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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