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Article

Regulation of leading edge microtubule and actin dynamics downstream of Rac1.

The Journal of cell biology - 9 Jun 2003

Wittmann Torsten, Bokoch Gary M, Waterman-Storer Clare M

Abstract excerpt

Actin in migrating cells is regulated by Rho GTPases. However, Rho proteins might also affect microtubules (MTs). Here, we used time-lapse microscopy of PtK1 cells to examine MT regulation downstream of Rac1. In these cells, "pioneer" MTs growing into leading-edge protrusions exhibited a decreased catastrophe frequency and an increased time in growth as compared with MTs further from the leading edge....

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Identifiers

PMID: 12796474
DOI: 10.1083/jcb.200303082
PMCID: PMC2172968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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