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Article

R-Ras controls membrane protrusion and cell migration through the spatial regulation of Rac and Rho.

Molecular biology of the cell - 1 Jan 2005

Wozniak Michele A, Kwong Lina, Chodniewicz David, Klemke Richard L, Keely Patricia J

Abstract excerpt

Although it is known that the spatial coordination of Rac and Rho activity is essential for cell migration, the molecular mechanisms regulating these GTPases during migration are unknown. We found that the expression of constitutively activated R-Ras (38V) blocked membrane protrusion and random migration. In contrast, expression of dominant negative R-Ras (41A) enhanced migrational persistence and membrane...

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Identifiers

PMID: 15525681
DOI: 10.1091/mbc.e04-04-0277
PMCID: PMC539154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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