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Article

A complex of p190RhoGAP-A and anillin modulates RhoA-GTP and the cytokinetic furrow in human cells.

Journal of cell science - 1 Jan 2015

Manukyan Arkadi, Ludwig Kirsten, Sanchez-Manchinelly Sergio, Parsons Sarah J, Stukenberg P Todd

Abstract excerpt

The cytokinetic furrow is organized by the RhoA GTPase, which recruits actin and myosin II to the furrow and drives contractility. Here, we show that the RhoA GTPase-activting protein (GAP) p190RhoGAP-A (also known as ARHGAP35) has a role in cytokinesis and is involved in regulating levels of RhoA-GTP and contractility. Cells depleted of p190RhoGAP-A accumulate high levels of RhoA-GTP and markers of high RhoA...

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Identifiers

PMID: 25359885
DOI: 10.1242/jcs.151647
PMCID: PMC4282047

Genes

ARHGAP35

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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