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Article

ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology.

The Journal of biological chemistry - 22 Feb 2013

Chen Pei-Wen, Jian Xiaoying, Yoon Hye-Young, Randazzo Paul A

Abstract excerpt

Focal adhesions (FAs) are dynamic structures that connect the actin cytoskeleton with the extracellular matrix. At least six ADP-ribosylation factor (Arf) GTPase-activating proteins (GAPs), including ARAP2 (an Arf6 GAP), are implicated in regulation of FAs but the mechanisms for most are not well defined. Although Rac1 has been reported to function downstream of Arf6 to control membrane ruffling and cell...

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Share to ADP-Ribosylation Factor 6
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Share to Cell Adhesion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Focal Adhesions

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Source

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Identifiers

PMID: 23295182
DOI: 10.1074/jbc.M112.415778
PMCID: PMC3581411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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