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Article

Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils.

Cell - 25 Jul 2003

Xu Jingsong, Wang Fei, Van Keymeulen Alexandra, Herzmark Paul, Straight Aaron, Kelly Kathleen, Takuwa Yoh, Sugimoto Naotoshi, Mitchison Timothy, Bourne Henry R

Abstract excerpt

Like neutrophilic leukocytes, differentiated HL-60 cells respond to chemoattractant by adopting a polarized morphology, with F-actin in a protruding pseudopod at the leading edge and contractile actin-myosin complexes at the back and sides. Experiments with pharmacological inhibitors, toxins, and mutant proteins show that this polarity depends on divergent, opposing "frontness" and "backness" signals generated by...

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Identifiers

PMID: 12887922
DOI: 10.1016/s0092-8674(03)00555-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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