Article

Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration

2016-09-21

Abstract excerpt

Efficient collective migration depends on a balance between contractility and cytoskeletal rearrangements, adhesion, and mechanical cell-cell communication, all controlled by GTPases of the RHO family. By comprehensive screening of guanine nucleotide exchange factors (GEFs) in human bronchial epithelial cell monolayers, we identified GEFs that are required for collective migration at large, such as SOS1 and β -PI...

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Literature Corpus work: 44d31178-5ec6-5b7e-8891-b03e304f323e
DOI: 10.1101/076125

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