Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leading the way: Directional sensing through phosphatidylinositol 3-kinase and other signaling pathways.

Journal of cell science - 1 Sept 2003

Merlot Sylvain, Firtel Richard A

Abstract excerpt

Chemoattractant-responsive cells are able to translate a shallow extracellular chemical gradient into a steep intracellular gradient resulting in the localization of F-actin assembly at the front and an actomyosin network at the rear that moves the cell forward. Recent evidence suggests that one of the first asymmetric cellular responses is the localized accumulation of PtdIns(3,4,5)P3, the product of class I...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actomyosin
Share to Cell Polarity
Share to Chemotaxis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dictyostelium

Share to Leukocytes

Share to Phosphatidylinositol Phosphates

Share to Phosphoric Monoester Hydrolases

Share to rho GTP-Binding Proteins

Source

Identifiers

PMID: 12893811
DOI: 10.1242/jcs.00703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leading the way: Directional sensing through phosphatidylinositol 3-kinase and other signaling pathways.PMID 12893811Read ↗

To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front.Semantic proximity Read ↗

Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils.Semantic proximity Read ↗

The excitable signal transduction networks: movers and shapers of eukaryotic cell migration.Semantic proximity Read ↗

Cell Migration: Integrating Signals from Front to BackSemantic proximity Read ↗

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.Semantic proximity Read ↗

Establishing direction during chemotaxis in eukaryotic cells.Semantic proximity Read ↗

The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration.Semantic proximity Read ↗

The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes.Semantic proximity Read ↗

Regulation of leading edge microtubule and actin dynamics downstream of Rac1.Semantic proximity Read ↗

Type I gamma phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration.Semantic proximity Read ↗

Chemotaxis: moving forward and holding on to the pastSemantic proximity Read ↗

Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G proteins at leading edges of moving NIH3T3 cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.