Article
CYP2C19 haplotypes in Koreans as a marker of enzyme activity evaluated with omeprazole.
Journal of clinical pharmacy and therapeutics - 1 Aug 2009
Jin S K, Kang T S, Eom S O, Kim J-I, Lee H J, Roh J
Abstract excerpt
BACKGROUND AND OBJECTIVE: CYP2C19 is clinically important in Korea because of the relatively high incidence of poor metabolizers in the population. To fully understand the genetic mechanism of the CYP2C19 defect in poor metabolizers, all variants need to be studied simultaneously. The aim of this study was to investigate the usefulness of CYP2C19 haplotypes as a marker of CYP2C19 enzyme activity in Koreans....
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